As the 2026/27 Bundesliga season kicks off, Bayer 04 Leverkusen welcomes 1. FSV Mainz 05 to the BayArena for an intriguing matchday 22 fixture. With both teams starting their campaigns without prior match experience, the outcome remains unpredictable. There are no previous head-to-head encounters to draw from, adding an extra layer of uncertainty to this matchup. Fans can expect both sides to be eager to make a strong impression in their season opener, with each looking to establish momentum early on. The community split on predictions reflects this uncertainty, with supporters divided on which team will claim the first victory of the season. As the excitement builds, make your predictions for what the score will be on TrendyAlpha.